1. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Theranostics. 2012;2(7):723-33. doi: 10.7150/thno.4275. Epub 2012 Aug 1.
Surface modification and functionalization of bioconjugated quantum dots (QDs) has drawn great attention for the past few years due to their wide applications in biomedical research. In this contribution, we demonstrate the use of PEGylated phospholipid micelles to encapsulate near infrared emitting ultra-small lead sulfide (PbS) QDs for in vitro and in vivo imaging. The cytotoxicity of the micelle-encapsulated QDs formulation was evaluated using MTS assay and histological analysis studies. We have found that upon encapsulating the QDs with phospholipid micelle, the toxicity of the PbS QDs is reduced, from which we envision that the PEGylated phospholipid micelle-encapsulated PbS QDs formulation can be used as theranostics probes for some selected applications in cell imaging and small animals study.
近年来，由于生物共轭量子点（QDs）在生物医学研究中的广泛应用，其表面修饰和功能化受到了极大的关注。在本研究中，我们展示了使用聚乙二醇化磷脂胶束来包封近红外发射的超小硫化铅（PbS）量子点，用于体外和体内成像。通过 MTS 测定和组织学分析研究评估了胶束包封的 QDs 制剂的细胞毒性。我们发现，通过用磷脂胶束包封 QDs，PbS QDs 的毒性降低，我们设想 PEG 化磷脂胶束包封的 PbS QDs 制剂可用于细胞成像和小动物研究中某些选定应用的治疗诊断探针。
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