Finogenova S A
Genetika. 1990 Dec;26(12):2240-5.
A variant of the model of single autosomal two-allele locus with incomplete and different for both sexes penetrance is under consideration. The variant may be used for revealing the effect of the major gene for determination of multifactorial disease encountered with different frequencies in men and women. Some approaches to obtaining the values of 7 parameters of the model under consideration are regarded on the basis of usually available data on probands' relatives.
正在考虑一种常染色体单基因座双等位基因模型的变体,该模型具有不完全且男女不同的外显率。该变体可用于揭示主基因对确定在男性和女性中以不同频率出现的多因素疾病的影响。基于通常可获得的先证者亲属的数据,探讨了获取所考虑模型的7个参数值的一些方法。