Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark.
Trends Cell Biol. 2010 Nov;20(11):662-71. doi: 10.1016/j.tcb.2010.08.011. Epub 2010 Sep 20.
Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.
组蛋白修饰作为调控标记，对于转录和染色质结构的控制至关重要。在发育和分化过程中，不同的细胞类型从共同的前体中进化而来，因此严格调控基因表达模式至关重要。自 2004 年首次发现组蛋白赖氨酸去甲基酶以来，已经鉴定出许多去甲基酶，并涉及到基因表达程序和细胞命运决定的控制。组蛋白去甲基酶现在作为发育过程中的重要参与者出现，并与神经紊乱和癌症等人类疾病有关。
