McGill University Health Center, Montreal, Quebec, Canada.
Am J Surg. 2011 Feb;201(2):245-50. doi: 10.1016/j.amjsurg.2010.02.009. Epub 2010 Sep 22.
Flat epithelial atypia (FEA) increasingly is being recognized as a pathologic entity on core needle biopsies. However, definitive management of this columnar cell lesion remains debatable because its malignant potential is unknown.
A PubMed search for "flat epithelial atypia" and "columnar cell lesions" was performed.
FEA commonly was encountered in the background of higher-grade lesions such as atypical ductal hyperplasia, ductal carcinoma in situ, and tubular and lobular carcinomas. Its molecular and cytogenetic profile revealed some alterations similar to precancerous lesions. Pure FEA on core needle biopsies was upgraded to higher-grade lesions on subsequent surgical excision.
Current management of FEA is best achieved through a multidisciplinary review considering various factors to determine if surgical excision is warranted. Further studies are required to elucidate the malignant potential of this columnar cell lesion.
在核心针活检中，越来越多的平坦上皮不典型（FEA）被认为是一种病理实体。然而，由于其恶性潜能未知，这种柱状细胞病变的明确处理仍存在争议。
对 PubMed 进行了“扁平上皮不典型”和“柱状细胞病变”的搜索。
FEA 通常见于高级别病变的背景下，如非典型导管增生、导管原位癌以及管状和小叶癌。其分子和细胞遗传学特征显示出与癌前病变相似的一些改变。在核心针活检中为单纯 FEA 的病变，在随后的外科切除中升级为高级别病变。
目前通过多学科审查来管理 FEA 是最佳方法，综合考虑各种因素以确定是否需要手术切除。需要进一步的研究来阐明这种柱状细胞病变的恶性潜能。
