Research Institute of Molecular Pathology, Dr. Bohrgasse 7, A-1030 Vienna, Austria.
Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a002055. doi: 10.1101/cshperspect.a002055. Epub 2010 Jun 9.
In a bilaterally symmetric animal, the midline plays a key role in directing axon growth during wiring of the nervous system. Midline cells provide a variety of guidance cues for growing axons, to which different types of axons respond in different ways and at different times. For some axons, the midline is an intermediate target. They first seek it out, but then move on towards their final targets on the opposite side. For others, the midline is a repulsive barrier that keeps them on their own side of the midline. And for many of these axons the midline provides signals that guide them along specific lateral pathways or up and down the longitudinal axis.
在双侧对称动物中，中线在神经系统布线过程中指导轴突生长方面起着关键作用。中线细胞为生长中的轴突提供了多种导向线索，不同类型的轴突以不同的方式和不同的时间对此做出反应。对于一些轴突来说，中线是一个中间目标。它们首先寻找它，但随后又向对侧的最终目标移动。对于另一些轴突来说，中线是一个排斥性的障碍，使它们保持在中线的同侧。对于这些轴突中的许多轴突来说，中线提供的信号引导它们沿着特定的侧方途径或沿着纵轴上下移动。
