Institute of Pathology, RWTH Aachen University, Aachen, Germany.
J Cancer Res Clin Oncol. 2010 Nov;136(11):1651-5. doi: 10.1007/s00432-010-0823-x. Epub 2010 Feb 21.
Hodgkin lymphoma (HL) is a distinctive lymphoma subtype characterized by rareness of tumor cells [Hodgkin's and Reed-Sternberg (HRS) cells in classical HL and lymphocytic and histiocytic cells in lymphocyte predominant HL] as well as the vast majority of the surrounding inflammatory-like cellular infiltrate. Still the onset of this highly variable disease is not completely understood. Proteome analysis can lead to the identification of potential proteins capable of elucidating malignant growth and survival in HL. Especially MALDI imaging could result in pinpointing differentially expressed proteins, which might represent potential marker molecules. In this study, we were able to distinguish between classical Hodgkin lymphoma and lymphadenitis with a sensitivity and specificity of 83.92 and 89.37%, respectively.
霍奇金淋巴瘤（HL）是一种独特的淋巴瘤亚型，其特征为肿瘤细胞稀少[经典 HL 中的 Hodgkin 氏和 Reed-Sternberg（HRS）细胞以及淋巴细胞为主型 HL 中的淋巴细胞和组织细胞]，以及绝大多数周围炎症样细胞浸润。尽管如此，这种高度多变的疾病的发病机制仍不完全清楚。蛋白质组分析可以鉴定出可能阐明 HL 中恶性生长和存活的潜在蛋白。特别是 MALDI 成像可以确定差异表达的蛋白，这些蛋白可能代表潜在的标记分子。在这项研究中，我们能够以 83.92%的灵敏度和 89.37%的特异性区分经典霍奇金淋巴瘤和淋巴结炎。
