Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.
Mol Oncol. 2010 Dec;4(6):529-38. doi: 10.1016/j.molonc.2010.09.002. Epub 2010 Sep 25.
MALDI Imaging Mass Spectrometry is a molecular analytical technology capable of simultaneously measuring multiple analytes directly from intact tissue sections. Histological features within the sample can be correlated with molecular species without the need for target-specific reagents such as antibodies. Several studies have demonstrated the strength of the technology for uncovering new markers that correlate with disease severity as well as prognosis and therapeutic response. This review describes technological aspects of imaging mass spectrometry together with applications in cancer research.
基质辅助激光解吸电离成像质谱技术是一种分子分析技术，能够直接从完整的组织切片中同时测量多种分析物。无需使用抗体等针对特定靶标的试剂，即可对样本中的组织学特征与分子种类进行相关联分析。多项研究表明，该技术在揭示与疾病严重程度以及预后和治疗反应相关的新标志物方面具有优势。本文综述了成像质谱技术的技术方面及其在癌症研究中的应用。
