Zorick F J, Roehrs T, Conway W, Potts G, Roth T
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202.
Henry Ford Hosp Med J. 1990;38(4):223-6.
Ninety-two consecutive patients with obstructive sleep apnea syndrome (OSAS) were studied before and six weeks after treatment with either nasal continuous positive airway pressure (CPAP) or uvulopalatopharyngoplasty (UPPP) (n = 46 per group). Assignment of patients to treatment was based on clinical considerations and patient preference. Patients were assessed by nocturnal polysomnography and performance on the Multiple Sleep Latency Test (MSLT) the following day. Before treatment, the CPAP and UPPP groups did not differ in sleep-related respiratory disturbance, oxygenation during sleep, fragmentation of sleep, or the level of excessive daytime sleepiness indicated by the MSLT. Both treatments produced significant improvement on all measures. However, improvement in UPPP patients was significantly less consistent than that of CPAP patients. To the extent that UPPP successfully reversed the respiratory disturbance (i.e., 50% reduction in respiratory events index), sleep continuity and daytime sleepiness were improved to a degree comparable to that of patients treated with CPAP.
对92例连续性阻塞性睡眠呼吸暂停综合征（OSAS）患者在接受鼻持续气道正压通气（CPAP）或悬雍垂腭咽成形术（UPPP）治疗前及治疗六周后进行了研究（每组46例）。患者的治疗分配基于临床考虑和患者偏好。通过夜间多导睡眠图以及次日多次睡眠潜伏期试验（MSLT）的表现对患者进行评估。治疗前，CPAP组和UPPP组在睡眠相关呼吸紊乱、睡眠期间的氧合、睡眠片段化或MSLT所显示的日间过度嗜睡程度方面并无差异。两种治疗方法在所有指标上均产生了显著改善。然而，UPPP患者的改善明显不如CPAP患者一致。在UPPP成功逆转呼吸紊乱的程度上（即呼吸事件指数降低50%），睡眠连续性和日间嗜睡程度改善至与接受CPAP治疗的患者相当的程度。
