Hendler B H, Costello B J, Silverstein K, Yen D, Goldberg A
Oral and Maxillofacial Surgery, The University of Pennsylvania Medical Center and School of Dental Medicine, Philadelphia, PA 19104, USA.
J Oral Maxillofac Surg. 2001 Aug;59(8):892-7; discussion 898-9. doi: 10.1053/joms.2001.25275.
This study evaluated the effectiveness of uvulopalatopharyngoplasty (UPPP) with mortised genioplasty and maxillomandibular advancement (MMA) for the treatment of patients with obstructive sleep apnea not controllable with appliances or continuous positive airway pressure.
Forty patients with obstructive sleep apnea were evaluated retrospectively. Thirty-three patients underwent combined UPPP and a modified mortised genioglossus advancement. Patients who had specific indications for MMA underwent combined procedures, eliminating staging of multiple surgeries. Seven patients were in this group. All patients were evaluated preoperatively and postoperatively with polysomnography to evaluate the efficacy of the treatment.
Mean respiratory distress indices (RDI) and nadir oxyhemoglobin desaturation values were significantly improved with each of the therapies despite many patients having body mass indices significantly greater than the average quoted in other studies. Patients with moderate sleep apnea (RDI, 21 to 40) who underwent UPPP/genioglossus advancement did very well, with 86% of patients achieving success. Patients who underwent MMA all decreased their RDI by at least 56% and had an average improvement of 86%.
The UPPP/mortised genioglossus advancement is effective for the treatment of obstructive sleep apnea. Maxillomandibular advancement is effective for treating severe sleep apnea and may, in some cases, be indicated in combination with UPPP/mortised genioglossus advancement to avoid multiple procedures. Surgical reconstruction of the upper airway is a reasonable approach to the treatment of patients with obstructive sleep apnea, and can be approached more directly to minimize repeated surgical intervention.
本研究评估悬雍垂腭咽成形术(UPPP)联合榫接颏成形术和上颌下颌前徙术(MMA)治疗经矫治器或持续气道正压通气治疗无效的阻塞性睡眠呼吸暂停患者的有效性。
对40例阻塞性睡眠呼吸暂停患者进行回顾性评估。33例患者接受了UPPP联合改良榫接颏舌肌前移术。有MMA特定指征的患者接受联合手术,避免了多次手术分期。该组有7例患者。所有患者术前和术后均进行多导睡眠图评估以评估治疗效果。
尽管许多患者的体重指数显著高于其他研究报道的平均水平,但每种治疗方法的平均呼吸窘迫指数(RDI)和最低氧合血红蛋白饱和度值均有显著改善。接受UPPP/颏舌肌前移术的中度睡眠呼吸暂停患者(RDI,21至40)效果良好,86%的患者取得成功。接受MMA的患者RDI均至少降低了56%,平均改善率为86%。
UPPP/榫接颏舌肌前移术对阻塞性睡眠呼吸暂停有效。上颌下颌前徙术对治疗重度睡眠呼吸暂停有效,并在某些情况下可能与UPPP/榫接颏舌肌前移术联合使用以避免多次手术。上气道手术重建是治疗阻塞性睡眠呼吸暂停患者的合理方法,并且可以更直接地进行以尽量减少重复手术干预。