Deveci Yasemin, Deveci Figen, Ilhan Nevin, Karaca Ilgın, Turgut Teyfik, Muz Mehmet Hamdi
Department of Chest Diseases, Faculty of Medicine, Fırat University, Elazığ, Turkey.
Tuberk Toraks. 2010;58(2):162-72.
It is determined that endocrine factors can play role on cachexia in chronic obstructive pulmonary disease (COPD). High levels of ghrelin is reported in cachectic COPD cases but its' relation couldn't shown statistically. In our study, it is aimed to detect serum ghrelin levels in COPD, its' relation with proinflammatory cytokines and whether serum ghrelin is associated with cachexia. Sixty stable COPD patients and 15 healthy volunteers were included in the study. COPD patients were divided into two groups, cachectic and normal weight, according to their body mass index. Spirometric assessments were performed and serum tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and ghrelin levels were measured in all cases. When COPD patients were compared with control group; serum ghrelin levels were statistically lower, TNF-a and IL-6 levels were statistically higher in COPD group. For cachectic COPD patients; serum ghrelin levels were statistically lower and IL-6 levels were statistically higher, compared with normal weight COPD patients. Although, serum TNF-a levels were higher for cachectic COPD patients; these levels were not significant. Positive correlation between serum ghrelin levels and body mass index was detected in patients with COPD. As a result; it is thought that increased proinflammatory cytokines and decreased serum active ghrelin levels may contribute to the development of weight loss.
已确定内分泌因素可在慢性阻塞性肺疾病（COPD）的恶病质中发挥作用。据报道，恶病质COPD患者的胃饥饿素水平较高，但其关系在统计学上未得到证实。在我们的研究中，旨在检测COPD患者的血清胃饥饿素水平、其与促炎细胞因子的关系以及血清胃饥饿素是否与恶病质相关。60例稳定期COPD患者和15名健康志愿者纳入研究。COPD患者根据体重指数分为两组，即恶病质组和正常体重组。对所有病例进行肺功能评估并测量血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和胃饥饿素水平。将COPD患者与对照组进行比较时；COPD组血清胃饥饿素水平在统计学上较低，TNF-α和IL-6水平在统计学上较高。对于恶病质COPD患者；与正常体重的COPD患者相比，血清胃饥饿素水平在统计学上较低，IL-6水平在统计学上较高。虽然，恶病质COPD患者的血清TNF-α水平较高；但这些水平无统计学意义。在COPD患者中检测到血清胃饥饿素水平与体重指数呈正相关。结果；认为促炎细胞因子增加和血清活性胃饥饿素水平降低可能有助于体重减轻的发生。
