1st Clinical Department of Cardiology, Swietokrzyskie Centre of Cardiology, Kielce, Poland.
Cardiol J. 2010;17(5):471-6.
Atrial fibrillation (AF) may result in endocardial endothelium dysfunction. The main objective of the study was to evaluate the plasma concentration of endothelin-1 (ET-1) during persistent AF and after sinus rhythm recovery following direct-current cardioversion and to assess the predictive value of ET-1 in AF patients.
The study group consisted of 43 patients with persistent AF and normal left ventricle systolic function who had undergone successful cardioversion. Blood samples were collected twice: 24 hours before and 24 hours after cardioversion. All patients were also examined in terms of sinus rhythm maintenance on the 30th day after cardioversion.
There were no differences in ET-1 plasma concentration between the persistent AF group and the control group (2.6 ± 2.9 fmol/mL vs 2.3 ± 4.5 fmol/mL, NS). Plasma ET-1 levels did not change within 24 hours after successful cardioversion (2.5 ± 2.8 fmol/mL vs 2.6 ± 2.9 fmol/mL, NS). There was no correlation between the baseline plasma levels of ET-1 in patients with persistent AF and sinus rhythm maintenance 30 days after cardioversion.
Persistent AF does not affect plasma ET-1 concentration in patients with normal left ventricle systolic function and with no symptoms of heart failure. There are no significant changes in plasma ET-1 level during the 24 hours after cardioversion.
心房颤动（AF）可能导致心内膜内皮功能障碍。本研究的主要目的是评估持续性 AF 患者直流电复律后恢复窦性心律时血浆内皮素-1（ET-1）浓度，并评估 ET-1 在 AF 患者中的预测价值。
研究组包括 43 例左心室收缩功能正常且成功复律的持续性 AF 患者。采集血液样本两次：复律前 24 小时和复律后 24 小时。所有患者还在复律后第 30 天检查窦性心律维持情况。
持续性 AF 组与对照组 ET-1 血浆浓度无差异（2.6±2.9 fmol/mL 比 2.3±4.5 fmol/mL，NS）。复律成功后 24 小时内，血浆 ET-1 水平无变化（2.5±2.8 fmol/mL 比 2.6±2.9 fmol/mL，NS）。持续性 AF 患者的基线血浆 ET-1 水平与复律后 30 天窦性节律维持之间无相关性。
持续性 AF 不会影响左心室收缩功能正常且无心力衰竭症状的患者的血浆 ET-1 浓度。复律后 24 小时内，血浆 ET-1 水平无明显变化。
