Division of Pediatric Neurology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Ann Neurol. 2010 Nov;68(5):762-6. doi: 10.1002/ana.22184.
The 2009 pandemic influenza A (H1N1) has been recognized to cause neurological complications including seizures and encephalopathy. We identified 18 children with 2009 H1N1 influenza and neurological complications from first and second wave activity, and compared characteristics to seasonal influenza. Seizures, encephalopathy, and status epilepticus were common presentations. Focal neurological symptoms persisted in 22% of patients at discharge. Compared to seasonal influenza, patients with pandemic 2009 influenza were more likely to have encephalopathy, focal neurological findings, aphasia, and abnormal electroencephalographic findings. In addition, we noted a trend toward heightened neurological complications following second wave influenza activity.
2009 年甲型 H1N1 流感大流行已被证实可引起包括癫痫发作和脑病在内的神经系统并发症。我们从第一波和第二波疫情中确定了 18 例患有 2009 年 H1N1 流感的伴有神经系统并发症的儿童，并将其特征与季节性流感进行了比较。癫痫发作、脑病和癫痫持续状态是常见的表现。出院时有 22%的患者存在局灶性神经症状持续存在。与季节性流感相比，患有大流行 2009 年流感的患者更有可能出现脑病、局灶性神经发现、失语症和异常脑电图发现。此外，我们注意到第二波流感活动后神经并发症有增加的趋势。
