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具有手性折叠均聚物的规范场理论及其在折叠蛋白质中的应用。

Gauge field theory of chirally folded homopolymers with applications to folded proteins.

作者信息

Danielsson Ulf H, Lundgren Martin, Niemi Antti J

机构信息

Department of Physics and Astronomy, Uppsala University, Sweden.

出版信息

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Aug;82(2 Pt 1):021910. doi: 10.1103/PhysRevE.82.021910. Epub 2010 Aug 11.

DOI:10.1103/PhysRevE.82.021910
PMID:20866840
Abstract

We combine the principle of gauge invariance with extrinsic string geometry to develop a lattice model that can be employed to theoretically describe properties of chiral, unbranched homopolymers. We find that in its low temperature phase the model is in the same universality class with proteins that are deposited in the Protein Data Bank, in the sense of the compactness index. We apply the model to analyze various statistical aspects of folded proteins. Curiously we find that it can produce results that are a very good good match to the data in the Protein Data Bank.

摘要

我们将规范不变性原理与外在弦几何相结合,开发出一种晶格模型,该模型可用于从理论上描述手性无支链均聚物的性质。我们发现,在其低温相中,就紧凑性指数而言,该模型与存于蛋白质数据库中的蛋白质属于同一普适类。我们应用该模型来分析折叠蛋白质的各种统计方面。奇怪的是,我们发现它能产生与蛋白质数据库中的数据非常吻合的结果。

相似文献

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Gauge field theory of chirally folded homopolymers with applications to folded proteins.具有手性折叠均聚物的规范场理论及其在折叠蛋白质中的应用。
Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Aug;82(2 Pt 1):021910. doi: 10.1103/PhysRevE.82.021910. Epub 2010 Aug 11.
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Topological solitons and folded proteins.拓扑孤子与折叠蛋白。
Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jul;82(1 Pt 1):011916. doi: 10.1103/PhysRevE.82.011916. Epub 2010 Jul 21.
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Soliton concepts and protein structure.孤子概念与蛋白质结构
Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Mar;85(3 Pt 1):031906. doi: 10.1103/PhysRevE.85.031906. Epub 2012 Mar 7.
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Characterization of the low-temperature properties of a simplified protein model.一种简化蛋白质模型的低温特性表征
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Force-induced conformational transition in a system of interacting stiff polymers: application to unfolding.相互作用的刚性聚合物体系中力诱导的构象转变:在解折叠中的应用
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Towards quantitative classification of folded proteins in terms of elementary functions.迈向基于基本功能的折叠蛋白质定量分类
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Designable structures are easy to unfold.可设计的结构易于展开。
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Compactness determines protein folding type.紧密性决定蛋白质折叠类型。
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引用本文的文献

1
On topology and knotty entanglement in protein folding.蛋白质折叠中的拓扑与纠结纠缠。
PLoS One. 2021 Jan 13;16(1):e0244547. doi: 10.1371/journal.pone.0244547. eCollection 2021.
2
Self-organized emergence of folded protein-like network structures from geometric constraints.从几何约束条件下自组织折叠蛋白样网络结构的形成。
PLoS One. 2020 Feb 27;15(2):e0229230. doi: 10.1371/journal.pone.0229230. eCollection 2020.
3
Topological Indices of Proteins.蛋白质的拓扑指数。
Sci Rep. 2019 Oct 10;9(1):14641. doi: 10.1038/s41598-019-50809-6.
4
Protein tertiary structure and the myoglobin phase diagram.蛋白质三级结构和肌红蛋白相图。
Sci Rep. 2019 Jul 25;9(1):10819. doi: 10.1038/s41598-019-47317-y.
5
Study of correlations between protein peptide plane dynamics and side chain dynamics.蛋白质肽面动力学与侧链动力学相关性研究。
PLoS One. 2019 Apr 12;14(4):e0215141. doi: 10.1371/journal.pone.0215141. eCollection 2019.
6
Clustering and percolation in protein loop structures.蛋白质环结构中的聚类与渗流
BMC Struct Biol. 2015 Oct 29;15:22. doi: 10.1186/s12900-015-0049-x.
7
Coexistence of phases in a protein heterodimer.蛋白质杂二聚体中各相的共存。
J Chem Phys. 2012 Jul 21;137(3):035101. doi: 10.1063/1.4734019.