Physicochimie Curie (Institut Curie/CNRS-UMR168/UPMC), Section de Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Phys Rev Lett. 2010 Jun 18;104(24):248102. doi: 10.1103/PhysRevLett.104.248102. Epub 2010 Jun 16.
We propose a two-state "soft-motor" model for the collective behavior of molecular motors which takes into account both the internal motor stiffness and the periodic interaction with the filament. As in the Prandtl-Tomlinson model of tribology, the important parameter of the model is the pinning parameter, which compares the stiffness of the motors to the stiffness of the potential. The model predicts dynamic instabilities in two disconnected regions of parameter space. These parameter ranges correspond to two existing theories of motor assemblies, the rigid two-state model and the crossbridge model. The model also predicts a discontinuity of the slope of the force-velocity relation at small velocities.
我们提出了一个双态“软马达”模型，用于描述分子马达的集体行为，该模型考虑了内部马达的刚度和与纤维的周期性相互作用。与摩擦学中的普朗特-汤姆林森模型一样，模型的重要参数是钉扎参数，它将马达的刚度与势的刚度进行比较。该模型预测了参数空间中两个不连续区域的动态不稳定性。这些参数范围对应于两种现有的马达组件理论，即刚性双态模型和交联桥模型。该模型还预测了在小速度下力-速度关系斜率的不连续性。
