Igari J
Department of Clinical Pathology, School of Medicine, Juntendo University.
Jpn J Antibiot. 1993 Jun;46(6):454-71.
This study was conducted to investigate susceptibilities of clinical isolates to antibacterial agents at 149 hospitals throughout Japan from September to December in both 1989 and 1990. In this study, identifications and susceptibility testings were carried out at each hospital laboratory. The susceptibility testings were performed according to the disk diffusion method recommended by NCCLS. Staphylococcus aureus and coagulase-negative staphylococci showed high or moderate resistance rates to beta-lactam antibiotics, but Streptococcus pyogenes and Streptococcus pneumoniae were highly susceptible to them. Enterococcus faecalis was susceptible to imipenem (IPM) and piperacillin but resistant to beta-lactam antibiotics and aminoglycosides. Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis were susceptible to beta-lactam drugs and aminoglycosides. Enterobacter cloacae, Serratia marcescens, Proteus vulgaris, Morganella morganii and Pseudomonas aeruginosa had a good susceptibility to IPM and aminoglycosides. Bacteroides fragilis was highly susceptible to IPM. IPM had strong antibacterial activity to many species of clinical isolates, including strains which were resistant to commonly used antibiotics.
本研究旨在调查1989年9月至12月以及1990年同期日本全国149家医院临床分离菌株对抗菌药物的敏感性。在本研究中，各医院实验室进行了菌株鉴定和药敏试验。药敏试验按照美国国家临床实验室标准委员会（NCCLS）推荐的纸片扩散法进行。金黄色葡萄球菌和凝固酶阴性葡萄球菌对β-内酰胺类抗生素呈现高或中度耐药率，但化脓性链球菌和肺炎链球菌对其高度敏感。粪肠球菌对亚胺培南（IPM）和哌拉西林敏感，但对β-内酰胺类抗生素和氨基糖苷类耐药。流感嗜血杆菌、大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌对β-内酰胺类药物和氨基糖苷类敏感。阴沟肠杆菌、粘质沙雷菌、普通变形杆菌、摩根摩根菌和铜绿假单胞菌对IPM和氨基糖苷类有良好的敏感性。脆弱拟杆菌对IPM高度敏感。IPM对许多临床分离菌株具有强大的抗菌活性，包括对常用抗生素耐药的菌株。
