Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, Würzburg, Germany.
Biol Chem. 2010 Nov;391(11):1265-79. doi: 10.1515/BC.2010.136.
The formation of reactive oxygen species (ROS) can be induced by xenobiotic substances, such as redox cycling molecules, but also by endogenous substances such as hormones and cytokines. Recent research shows the importance of ROS in cellular signaling. Here, the signaling pathways of the two blood pressure-regulating hormones angiotensin II and aldosterone are presented, focusing on both their physiological effects and the change of signaling owing to the action of increased concentrations or prolonged exposure. When present in high concentrations, both angiotensin II and aldosterone, as various other endogenous substances, activate NADPH oxidase, which produces superoxide. In this review the generation of superoxide anions and hydrogen peroxide in cells stimulated with angiotensin II or aldosterone, as well as the subsequently induced signaling processes and DNA damage is discussed.
活性氧 (ROS) 的形成可被外源物质（如氧化还原循环分子）或内源性物质（如激素和细胞因子）诱导。最近的研究表明 ROS 在细胞信号转导中的重要性。在这里，呈现了两种调节血压的激素——血管紧张素 II 和醛固酮的信号通路，重点介绍了它们的生理作用以及由于浓度增加或暴露时间延长而导致的信号变化。当存在于高浓度时，血管紧张素 II 和醛固酮与其他各种内源性物质一样，激活 NADPH 氧化酶，从而产生超氧阴离子。在这篇综述中，讨论了在受到血管紧张素 II 或醛固酮刺激的细胞中生成超氧阴离子和过氧化氢以及随后诱导的信号转导过程和 DNA 损伤。
