Campos-Esparza Maria del Rosario, Torres-Ramos Mónica Adriana
Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, México.
Cent Nerv Syst Agents Med Chem. 2010 Dec 1;10(4):269-77. doi: 10.2174/187152410793429728.
Polyphenols are the most abundant antioxidants in diet. These can be found in fruits, vegetables, beverages (tea, wine, juices, etc.), plants and some herbs. These compounds are capable of protecting neuronal cells in different in vivo and in vitro models through diverse intracellular targets. The focus of this review is aimed at presenting the role of some polyphenols on the molecular mechanism involve in neuroprotection through different biological processes like oxidative stress, excitotoxicity, apoptotic neuronal death, regulation of the kinase signal cascade and modulation of Ubiquitin-Proteasome pathway. The study of the molecular mechanisms involved in neuroprotection and the molecular targets of natural polyphenols are important in the discovery of a valuable tool for new and more advanced therapy in neurodegenerative diseases.
多酚是饮食中最丰富的抗氧化剂。它们存在于水果、蔬菜、饮料（茶、葡萄酒、果汁等）、植物和一些草药中。这些化合物能够通过不同的细胞内靶点在不同的体内和体外模型中保护神经元细胞。本综述的重点是介绍一些多酚在神经保护中的作用，这些作用涉及氧化应激、兴奋性毒性、凋亡性神经元死亡、激酶信号级联调节和泛素-蛋白酶体途径调节等不同生物学过程。对神经保护所涉及的分子机制以及天然多酚的分子靶点的研究，对于发现一种用于神经退行性疾病新的更先进治疗的有价值工具具有重要意义。
