Biesalski Hans K
Department of Biological Chemistry and Nutrition, University Hohenheim, Stuttgart, Germany.
Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):724-8. doi: 10.1097/MCO.0b013e3282f0cef2.
For more than 20 years polyphenols, food-derived bioactive compounds in fruits and vegetables, are claimed to help prevent cancer, degenerative diseases and chronic and acute inflammation. Modern methods in cell and molecular biology allow us to understand the interactions of different polyphenols with basic mechanisms of inflammatory response. This review summarizes recent papers dealing with the effect of polyphenols on modulators of the inflammatory cascade.
The majority of papers deal with the effects of different antioxidants on the redox sensitive transcription factor nuclear factor kappaB, inducible nitric oxide synthase expression and cyclooxygenase inhibition. Understanding the regulatory steps and the multiple potential actions of polyphenols within the inflammatory cascade may help to define special polyphenols to be used for prevention and intervention in clinical conditions of inflammation. The relation between formation of advanced glycation end products as a consequence of high glucose and the activation of defence mechanisms through polyphenols opens new fields in the prevention and treatment of oxidative stress and hyperglycemia.
Polyphenols are promising compounds that may help to control oxidative stress and consequently inflammatory response. To date, however, clinical studies are missing and should be carried out with specific polyphenols.
二十多年来，水果和蔬菜中源自食物的生物活性化合物多酚，一直被认为有助于预防癌症、退行性疾病以及急慢性炎症。细胞与分子生物学的现代方法使我们能够了解不同多酚与炎症反应基本机制之间的相互作用。本综述总结了近期有关多酚对炎症级联反应调节因子影响的论文。
大多数论文探讨了不同抗氧化剂对氧化还原敏感转录因子核因子κB、诱导型一氧化氮合酶表达以及环氧化酶抑制的影响。了解多酚在炎症级联反应中的调控步骤和多种潜在作用，可能有助于确定用于预防和干预临床炎症状况的特定多酚。高血糖导致的晚期糖基化终产物形成与多酚激活防御机制之间的关系，为氧化应激和高血糖的预防与治疗开辟了新领域。
多酚是有前景的化合物，可能有助于控制氧化应激并进而控制炎症反应。然而，迄今为止尚缺乏临床研究，应当针对特定多酚开展此类研究。
