Department of Women's and Children's Health, Uppsala University, Sweden.
Acta Paediatr. 2011 Feb;100(2):220-5. doi: 10.1111/j.1651-2227.2010.02011.x. Epub 2010 Oct 4.
To estimate the prevalence of infant anaemia and its association with iron deficiency, growth, infection and other micronutrient deficiencies.
Using data from MINIMat, a randomized maternal food and micronutrient supplementation trial, we assessed the associations between anaemia (haemoglobin < 105 g/L) in 580 infants at 6 months and deficiencies of iron, vitamin A, vitamin B12, zinc and folate, infection and anthropometric indices. Variables associated with anaemia in bivariate analyses were evaluated in logistic regression models, adjusting for potential confounders.
Anaemia was found in 46% of the infants, and among these, 28% had iron deficiency (plasma ferritin <9 μg/L). Elevated C-reactive protein (>10mg/L) (OR = 2.7, 95% CI: 1.6, 4.7), low birthweight (OR = 2.3, 95% CI: 1.5, 3.5) and iron deficiency (OR = 2.2, 95% CI: 1.4, 3.6) were independently associated with increased risk for anaemia. We also observed a seasonal variation in anaemia not mediated through the other factors studied.
In a cohort in rural Bangladesh, anaemia at age 6 months was common and associated with infection, low birthweight and iron deficiency.
评估婴儿贫血的患病率及其与缺铁、生长、感染和其他微量营养素缺乏的关系。
利用 MINIMat 随机孕产妇食物和微量营养素补充试验的数据，我们评估了 580 名 6 个月大婴儿的贫血（血红蛋白<105g/L）与铁、维生素 A、维生素 B12、锌和叶酸缺乏、感染和人体测量指数之间的关系。在双变量分析中与贫血相关的变量在逻辑回归模型中进行评估，同时调整了潜在的混杂因素。
46%的婴儿出现贫血，其中 28%有缺铁（血浆铁蛋白<9μg/L）。C 反应蛋白升高（>10mg/L）（OR=2.7，95%CI：1.6，4.7）、低出生体重（OR=2.3，95%CI：1.5，3.5）和缺铁（OR=2.2，95%CI：1.4，3.6）与贫血风险增加独立相关。我们还观察到贫血存在季节性变化，而这种变化不受其他研究因素的影响。
在孟加拉国农村的一个队列中，6 个月大的婴儿贫血很常见，与感染、低出生体重和缺铁有关。
