Department of Dermatology, St. Luke's- Roosevelt Hospital Center, New York, NY, USA.
J Cutan Med Surg. 2010 Sep-Oct;14(5):212-22. doi: 10.2310/7750.2010.09055.
Few studies have investigated central centrifugal cicatricial alopecia (CCCA). Thus, our understanding of CCCA is largely based on anecdotal evidence.
The purpose of this study was to investigate clinical characteristics and hair care practices in CCCA patients.
We conducted a single-center retrospective chart review of patients with a clinicopathologic diagnosis of CCCA.
Medical records of 69 patients were reviewed. Of these, 97% were female. The mean ages at onset and presentation were 38.2 and 42.4 years, respectively. All subjects for whom hair care data were available had used a traumatic practice at least once, the most common being chemical relaxer. Family history data were available for 27 subjects (39%). Of these, 56% had a positive family history of hair loss. Seborrheic dermatitis was the leading concurrent diagnosis.
Limitations include lack of a control group, retrospective design, and selection bias.
Our results confirm that CCCA primarily affects adult women of African descent. The majority of patients presented several years after onset, suggesting that efforts to encourage earlier diagnosis are warranted. Although the role of hair care remains unclear, traumatic practices were reported in all patients in our study for whom hair care was documented.
鲜有研究调查中央离心性瘢痕性脱发（CCCA）。因此，我们对 CCCA 的认识主要基于传闻证据。
本研究旨在调查 CCCA 患者的临床特征和头发护理习惯。
我们对经临床病理诊断为 CCCA 的患者进行了单中心回顾性病历审查。
共回顾了 69 名患者的病历。其中，97%为女性。发病和就诊的平均年龄分别为 38.2 岁和 42.4 岁。所有可提供头发护理数据的患者至少使用过一次创伤性护理方法，最常见的是化学拉直。有 27 名患者（39%）可提供家族史数据。其中，56%有脱发的阳性家族史。脂溢性皮炎是最常见的并发诊断。
本研究的局限性包括缺乏对照组、回顾性设计和选择偏倚。
我们的研究结果证实 CCCA 主要影响非洲裔成年女性。大多数患者在发病后数年才就诊，这表明有必要鼓励更早诊断。虽然头发护理的作用仍不清楚，但在我们研究中所有记录头发护理的患者中都报告了创伤性护理。
