胰岛素/IGF-1 信号通路的遗传变异与长寿。
Genetic variation in insulin/IGF-1 signaling pathways and longevity.
机构信息
Department of Medicine, Institute for Human Genetics, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 94143-3116, United States.
出版信息
Ageing Res Rev. 2011 Apr;10(2):201-4. doi: 10.1016/j.arr.2010.09.002. Epub 2010 Sep 22.
The insulin/IGF-1 pathway has been shown to affect lifespan and rate of aging in a variety of animals including worms, flies and mice. Genetic variation in this pathway may also affect human longevity. We review the evidence for the effect of this pathway on longevity with a focus on the genetic studies in humans to date. One gene, FOXO3A, a transcriptional factor homologous to daf-16, has been repeatedly associated with increased lifespan in several studies in different ethnic populations.
胰岛素/IGF-1 通路已被证明可影响多种动物（包括蠕虫、苍蝇和老鼠）的寿命和衰老速度。该通路中的遗传变异也可能影响人类的长寿。我们回顾了该通路对长寿影响的证据，重点是迄今为止人类的遗传研究。一个基因 FOXO3A，一种与 daf-16 同源的转录因子，已在不同种族人群的几项研究中反复与寿命延长相关联。
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