CRLC Val d'Aurelle-Paul Lamarque, Radiation Oncology Department, Rue Croix Verte, Montpellier Cedex 5, France.
Crit Rev Oncol Hematol. 2012 Dec;84 Suppl 1:e35-41. doi: 10.1016/j.critrevonc.2010.08.003. Epub 2010 Sep 24.
The impact of curative radiotherapy depends mainly on the total dose delivered in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many treatments. Two different side effects (acute and late) can occur during and after radiotherapy. Of particular interest are the radiation-induced late complications (LC) due to their irreversibility and the potential impact on quality of life. In one population treated with the same technique, it appears that individual radiosensitivity clearly exists. In the hypothesis that genetic is involved in this area of research, low CD4 and CD8 lymphocyte apoptosis were shown to be correlated with high grade of LC. In addition, recent data suggest that patients with severe radiation-induced LC possess 4 or more single nucleotide polymorphisms (SNPs) in candidate genes and low radiation-induced CD8 lymphocyte apoptosis in vitro. On-going studies are being analyzing the entire genome using a genome-wide association study (GWAS).
根治性放疗的效果主要取决于靶区的总剂量。然而，周围健康组织的剂量可能会降低许多治疗方法的治疗效果比。放疗过程中和放疗后会出现两种不同的副作用（急性和晚期）。特别值得关注的是放射性迟发性并发症（LC），因为它们是不可逆转的，并且可能会对生活质量产生影响。在接受相同技术治疗的人群中，显然存在个体放射敏感性。在遗传因素可能涉及这一研究领域的假设下，低 CD4 和 CD8 淋巴细胞凋亡与 LC 高分级相关。此外，最近的数据表明，患有严重放射性 LC 的患者在候选基因中具有 4 个或更多的单核苷酸多态性（SNP），并且体外辐射诱导的 CD8 淋巴细胞凋亡减少。目前正在进行的研究使用全基因组关联研究（GWAS）分析整个基因组。
