多聚谷氨酰胺病：过多的 Q，过多的功能？
PolyQ disease: too many Qs, too much function?
机构信息
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA.
出版信息
Neuron. 2010 Sep 23;67(6):897-9. doi: 10.1016/j.neuron.2010.09.012.
Abstract
The nature of the gain-of-function toxicity found in polyglutamine (polyQ) diseases has been the subject of considerable debate. In this issue of Neuron, Duvick et al. and Nedelsky et al. show that, in two of these diseases, pathology is mediated by normal protein activity.
摘要
在多聚谷氨酰胺（polyQ）疾病中发现的功能获得毒性的本质一直是相当有争议的话题。在本期神经元杂志上，Duvick 等人和 Nedelsky 等人表明，在其中两种疾病中，病理学是由正常蛋白质活性介导的。
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