Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street; PO Box 980678, Richmond, VA 23298-0678, USA.
Virology. 2010 Nov 25;407(2):381-90. doi: 10.1016/j.virol.2010.08.036. Epub 2010 Sep 25.
Staphylococcus aureus pathogenicity islands (SaPIs) are mobile elements that are induced by a helper bacteriophage to excise and replicate and to be encapsidated in phage-like particles smaller than those of the helper, leading to high-frequency transfer. SaPI mobilization is helper phage specific; only certain SaPIs can be mobilized by a particular helper phage. Staphylococcal phage 80α can mobilize every SaPI tested thus far, including SaPI1, SaPI2 and SaPIbov1. Phage 80, on the other hand, cannot mobilize SaPI1, and ϕ11 mobilizes only SaPIbov1. In order to better understand the relationship between SaPIs and their helper phages, the genomes of phages 80 and 80α were sequenced, compared with other staphylococcal phage genomes, and analyzed for unique features that may be involved in SaPI mobilization.
金黄色葡萄球菌致病性岛（SaPIs）是可移动的遗传元件，由辅助噬菌体诱导切割、复制和包装成小于辅助噬菌体的噬菌体样颗粒，从而导致高频转移。SaPI 的移动是辅助噬菌体特异性的；只有特定的 SaPIs 可以被特定的辅助噬菌体移动。迄今为止，葡萄球菌噬菌体 80α 可以移动所有测试过的 SaPI，包括 SaPI1、SaPI2 和 SaPIbov1。另一方面，噬菌体 80 不能移动 SaPI1，而 ϕ11 只能移动 SaPIbov1。为了更好地理解 SaPIs 与其辅助噬菌体之间的关系，对噬菌体 80 和 80α 的基因组进行了测序，并与其他葡萄球菌噬菌体基因组进行了比较，分析了可能参与 SaPI 移动的独特特征。
