Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United States.
Bioorg Med Chem Lett. 2010 Nov 15;20(22):6716-20. doi: 10.1016/j.bmcl.2010.08.143. Epub 2010 Sep 6.
As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.
作为鉴定 Schweinfurthin 结合蛋白的前期工作，我们通过化学合成制备了 Schweinfurthin F 的酯结合物和酰胺结合物以及生物素。这些化合物在 SF-295 细胞中的活性与母体系统相当，并且在 A549 细胞中的活性较低，这是 Schweinfurthin 活性模式的特征。
