Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India.
J Clin Neurosci. 2011 Mar;18(3):334-9. doi: 10.1016/j.jocn.2010.05.031. Epub 2010 Sep 24.
Central neurocytomas are low-grade tumors of neuronal origin located in the lateral ventricle that present predominantly with raised intracranial pressure. In this retrospective study, we investigated the clinical, radiological, histopathological and immunohistochemical features of eight patients (seven males and one female; age range 16-61 years; mean=35.1 years) with neurocytoma. Raised intracranial pressure was the most common presenting feature. In addition, one patient presented with marked visual deterioration and one presented with a visual field defect. All lesions were located in the lateral ventricle (right lateral ventricle: four patients, left lateral ventricle: three patients, both ventricles: one patients). Radiology showed marked intratumoral calcification in two patients. Total microsurgical excision was achieved in seven patients. Histopathology showed sheets of monotonously small-to-medium-sized neoplastic cells with uniform round-to-oval nuclei and inconspicuous nucleoli. Immunohistochemistry was positive for synaptophysin and neuron-specific enolase (NSE) in all tumors, and glial fibrillary acidic protein was focally positive in two patients. One patient had lipomatous differentiation within the tumor. No recurrence was noted in any of our patients until the last follow-up; however, there were two deaths in our series.
中枢神经细胞瘤是起源于神经元的低级别的脑肿瘤，位于侧脑室内，主要表现为颅内压升高。在这项回顾性研究中，我们调查了 8 例神经细胞瘤患者（7 名男性和 1 名女性；年龄 16-61 岁；平均年龄 35.1 岁）的临床、影像学、组织病理学和免疫组织化学特征。颅内压升高是最常见的首发症状。此外，1 例患者表现为明显的视力恶化，1 例患者表现为视野缺损。所有病变均位于侧脑室内（右侧侧脑室 4 例，左侧侧脑室 3 例，双侧脑室 1 例）。影像学显示 2 例肿瘤内有明显的钙化。7 例患者均行全显微镜下切除术。组织病理学显示肿瘤细胞呈均匀的小圆到中等大小的细胞片状排列，细胞核均匀圆形到卵圆形，核仁不明显。所有肿瘤的免疫组织化学均为突触素和神经元特异性烯醇化酶（NSE）阳性，2 例患者的神经胶质纤维酸性蛋白呈局灶性阳性。1 例患者的肿瘤内有脂肪分化。在最后一次随访时，我们所有的患者均未复发，但本研究中有 2 例死亡。
