Miyagi A, Kido G, Miyagami M, Tsubokawa T
Department of Neurosurgery, Nihon University, School of medicine, Tokyo, Japan.
No To Shinkei. 1993 Jan;45(1):77-83.
The authors present a case of central neurocytoma in a 23-year-old male with increased intracranial pressure syndrome. Computed tomographic (CT) scans and magnetic resonance images showed a large tumor mass with no evidence of calcification in the right lateral ventricle extending towards the third ventricle. A right transcortical-transventricular approach was performed and the tumor was totally removed. The postoperative course was uneventful and no further treatment was administered. CT shows no evidence of tumor recurrence after the six months from his surgery. Light microscopic findings suggested a diagnosis of oligodendroglioma. However, ultrastructural examinations demonstrated many dense-core or clear vesicles, microtubules and synaptic like structures within the abundant cytoplasmic processes of the tumor cells which suggested neuronal differentiation. Immunohistochemical examinations showed the tumor cells to be positive for neuron-specific enolase, sporadically positive for synaptophysin, and negative for glial fibrillary acidic protein. The final histological diagnosis was central neurocytoma. Central neurocytoma was first described by Hassoun et al, in 1982. Since then, 96 cases have been reported in the literatures. Their clinicopathological features, neuroradiological findings and prognosis are discussed.
作者报告了一例23岁患有颅内压增高综合征的男性中枢神经细胞瘤病例。计算机断层扫描（CT）和磁共振成像显示右侧脑室有一个大的肿瘤肿块，没有钙化迹象，该肿瘤向第三脑室延伸。采用右侧经皮质-经脑室入路，肿瘤被完全切除。术后过程平稳，未进行进一步治疗。术后六个月的CT检查未显示肿瘤复发迹象。光镜检查结果提示为少突胶质细胞瘤诊断。然而，超微结构检查显示肿瘤细胞丰富的胞质突起内有许多致密核心或清亮小泡、微管和突触样结构，提示神经元分化。免疫组化检查显示肿瘤细胞神经元特异性烯醇化酶呈阳性，突触素散在阳性，胶质纤维酸性蛋白呈阴性。最终组织学诊断为中枢神经细胞瘤。中枢神经细胞瘤于1982年由哈苏恩等人首次描述。自那时以来，文献中已报道96例。文中讨论了它们的临床病理特征、神经放射学表现和预后。
