不同钙浓度对大鼠输精管突触前α-肾上腺素能受体抑制作用的影响。
The effect of different calcium concentrations on the inhibitory effect of presynaptic alpha-adrenoceptors in the rat vas deferens.
作者信息
Drew G M
出版信息
Br J Pharmacol. 1978 Jul;63(3):417-9. doi: 10.1111/j.1476-5381.1978.tb07792.x.
Abstract
The effects of different calcium concentrations on the twitch-inhibitory potency of clonidine and of guanethidine have been examined in the rat isolated vas deferens. Vasa deferentia did not respond to field stimulation at 0.3 Hz in Krebs solution containing 0.325 mmol/1 of calcium. Increasing the calcium concentration to 5.2 mmol/1 caused a concentration-dependent increase in size of the twitch response. The twitch inhibitory potency of clonidine was inversely proportional to the calcium concentration. The inhibitory effect of guanethidine was not influenced by changes in calcium concentration. The results show that the modulation of motor function by presynaptic alpha-adrenoceptors in the rat vas deferens is calcium-dependent.
摘要
在大鼠离体输精管中研究了不同钙浓度对可乐定和胍乙啶的抽搐抑制效力的影响。在含有0.325 mmol/L钙的Krebs溶液中，输精管对0.3 Hz的场刺激无反应。将钙浓度增加到5.2 mmol/L导致抽搐反应大小呈浓度依赖性增加。可乐定的抽搐抑制效力与钙浓度成反比。胍乙啶的抑制作用不受钙浓度变化的影响。结果表明，大鼠输精管中突触前α-肾上腺素能受体对运动功能的调节是钙依赖性的。
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