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Br J Pharmacol. 1980;71(1):113-20. doi: 10.1111/j.1476-5381.1980.tb10916.x.
2
Effects of St-587 on the alpha-adrenoceptors in the bisected rat vas deferens.St-587对大鼠离体输精管α-肾上腺素能受体的影响。
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4
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Eur J Pharmacol. 1980 Oct 3;67(1):33-40. doi: 10.1016/0014-2999(80)90005-9.

引用本文的文献

1
Hypotensive and bradycardic effects of talipexole (B-HT 920) in anaesthetized rabbits are antagonized by metoclopramide but not by yohimbine.甲磺酸泰利必利（B-HT 920）对麻醉兔的降压和心动过缓作用可被甲氧氯普胺拮抗，但不能被育亨宾拮抗。
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7
Metoclopramide, domperidone and dopamine in man: actions and interactions.甲氧氯普胺、多潘立酮与人的多巴胺：作用及相互作用
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SYMPATHETIC BETA-RECEPTORS AND THE GUINEA-PIG VAS DEFERENS.交感β受体与豚鼠输精管
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[ANTIEMETIC ACTION OF METOCLOPRAMIDE WITH RESPECT TO APOMORPHINE AND HYDERGINE].[胃复安对阿扑吗啡和海得琴的止吐作用]
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Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
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[Clinical and electroencephalographic effects of methoclopramide in psychiatry].甲氧氯普胺在精神病学中的临床及脑电图效应
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The effects of cocaine, norepinephrine and ionic stimulants on the isolated, superfused rat vas deferens: antagonism by "adrenergic neuron blockers" and reserpine.可卡因、去甲肾上腺素和离子兴奋剂对离体灌流大鼠输精管的作用：“肾上腺素能神经元阻断剂”和利血平的拮抗作用。
J Pharmacol Exp Ther. 1971 Apr;177(1):136-45.
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The presence of -adrenoceptors in the guinea-pig seminal vesicle.豚鼠精囊内β-肾上腺素能受体的存在。
Br J Pharmacol. 1972 May;45(1):21-8. doi: 10.1111/j.1476-5381.1972.tb09572.x.
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Adrenergic beta receptors in vas deferens.输精管中的肾上腺素能β受体。
Arch Int Pharmacodyn Ther. 1970 Jun;185(2):406-12.
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Inhibition of post-ganglionic motor transmission in vas deferens by indirectly acting sympathomimetic drugs.间接作用拟交感神经药对输精管节后运动传递的抑制作用。
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9
Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission.刺激持续时间和频率对肾上腺素能传递中α-肾上腺素能受体刺激引起的突触前抑制的影响。
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Comparative psychotropic effects of metoclopramide and prochlorperazine in normal subjects.甲氧氯普胺与氯丙嗪对正常受试者的精神药物比较效应
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胃复安和异丙肾上腺素对大鼠输精管的作用；与α-肾上腺素能受体的相互作用。

Effects of metoclopramide and isoprenaline in the rat vas deferens; interactions with alpha-adrenoceptors.

作者信息

Spedding M

出版信息

Br J Pharmacol. 1980;71(1):113-20. doi: 10.1111/j.1476-5381.1980.tb10916.x.

DOI:10.1111/j.1476-5381.1980.tb10916.x
PMID:6258684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044435/
Abstract

1 Metoclopramide (2.8 to 280 microM) augmented contractions of rat vas deferens preparations induced by field stimulation (6 Hz for 1 s). This effect was antagonized by phentolamine (0.1 microM). Metoclopramide (2.8 to 280 microM) did not affect phenylephrine-induced contractions. 2 Metoclopramide (2.8 to 280 microM) antagonized the inhibitory effects of clonidine on the contractions induced by field stimulation, but not the inhibitory effects of purine nucleosides. 3 From these results it is concluded that metoclopramide (2.8 to 280 microM) is a presynaptic alpha-adrenoceptor antagonist in the rat vas deferens. 4 Following beta-adrenoceptor blockade with (+/-)-propranolol (3.3 microM), (-)-isoprenaline (0.47 to 14 microM) inhibited responses to field stimulation but not to phenylephrine. These propranolol-resistant effects of isoprenaline were antagonized by metoclopramide (2.8 to 280 microM) and by phentolamine (0.1 to 10 microM), indicating that isoprenaline may stimulate presynaptic alpha-adrenoceptors in this preparation.

摘要

1 胃复安（2.8至280微摩尔）增强了大鼠输精管标本由场刺激（6赫兹，持续1秒）诱导的收缩。这种作用被酚妥拉明（0.1微摩尔）拮抗。胃复安（2.8至280微摩尔）不影响去氧肾上腺素诱导的收缩。2 胃复安（2.8至280微摩尔）拮抗可乐定对场刺激诱导收缩的抑制作用，但不拮抗嘌呤核苷的抑制作用。3 从这些结果得出结论，胃复安（2.8至280微摩尔）是大鼠输精管中的一种突触前α-肾上腺素能受体拮抗剂。4 在用（±）-普萘洛尔（3.3微摩尔）阻断β-肾上腺素能受体后，（-）-异丙肾上腺素（0.47至14微摩尔）抑制对场刺激的反应，但不抑制对去氧肾上腺素的反应。异丙肾上腺素的这些普萘洛尔抗性作用被胃复安（2.8至280微摩尔）和酚妥拉明（0.1至10微摩尔）拮抗，表明异丙肾上腺素可能在此标本中刺激突触前α-肾上腺素能受体。