Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, CA 92182-1010, USA.
J Bacteriol. 2010 Nov;192(22):6086-8. doi: 10.1128/JB.00649-10. Epub 2010 Sep 24.
A fitness cost due to imbalanced replichores has been proposed to provoke chromosome rearrangements in Salmonella enterica serovars. To determine the impact of replichore imbalance on fitness, the relative fitness of isogenic Salmonella strains containing transposon-held duplications of various sizes and at various chromosomal locations was determined. Although duplication of certain genes influenced fitness, a replichore imbalance of up to 16° did not affect fitness.
由于复制子不平衡而导致的适应代价被认为会引发沙门氏菌血清型的染色体重排。为了确定复制子不平衡对适应度的影响,测定了含有转座子介导的各种大小和不同染色体位置重复的同基因沙门氏菌菌株的相对适应度。尽管某些基因的重复会影响适应度,但高达 16°的复制子不平衡不会影响适应度。