Oette K
Institut für Klinische Chemie, Universität Köln.
Klin Wochenschr. 1990;68 Suppl 22:7-11.
In accordance with metabolic properties in the mucosal and liver cells, the exogenous fatty acids may be classified as short chain (C4 and C6), medium chain (C8 and C10), transitional (C12 and C14) and long chain (C16 upward) fatty acids. The postprandial fatty acid metabolism takes place in two phases. In the first, approximately 8 hour phase, the clearance of chylomicrons and most of the chylomicron remnants as well as the uptake of short and medium chain fatty acids by the liver are completed. Most of the exogenous long chain fatty acids (chylomicron fatty acids) are cleared extrahepatically. However, about 10% of the long chain fatty acids are taken up by the liver, and during the second postprandial phase, lasting about 24 hours, the liver secretes most of these exogenous fatty acids with very low density lipoproteins. The exogenous fatty acids may circulate between the liver and adipose tissue until they are finally metabolized mainly in extrahepatic tissues.
根据黏膜和肝细胞中的代谢特性,外源性脂肪酸可分为短链(C4和C6)、中链(C8和C10)、过渡链(C12和C14)和长链(C16及以上)脂肪酸。餐后脂肪酸代谢分两个阶段进行。在第一个约8小时的阶段,乳糜微粒和大多数乳糜微粒残粒的清除以及肝脏对短链和中链脂肪酸的摄取完成。大多数外源性长链脂肪酸(乳糜微粒脂肪酸)在肝外被清除。然而,约10%的长链脂肪酸被肝脏摄取,在餐后的第二个阶段,持续约24小时,肝脏以极低密度脂蛋白的形式分泌这些外源性脂肪酸中的大部分。外源性脂肪酸可能在肝脏和脂肪组织之间循环,直到它们最终主要在肝外组织中被代谢。