Jacob P, Lewis E R, Elias-Baker B A, Jones R T
Drug Dependence Research Center, Langley Porter Psychiatric Institute, University of California, San Francisco 94143.
J Anal Toxicol. 1990 Nov-Dec;14(6):353-7. doi: 10.1093/jat/14.6.353.
A method using combined gas chromatography/mass spectrometry (GC/MS) for determination of the cocaine pyrolysis product anhydroecgonine methyl ester (AEME) in urine is described. Using this method, we found that human subjects who smoked cocaine under laboratory conditions excreted substantial amounts of AEME in their urine. Little, if any, AEME was excreted in the urine when the same subjects were administered cocaine by intravenous and intranasal routes. AEME may be a useful marker for cocaine (crack) smoking. The pharmacology of AEME is unknown. The possibility that AEME may play a role in the effects associated with cocaine smoking needs to be examined.
描述了一种使用气相色谱/质谱联用（GC/MS）测定尿液中可卡因热解产物脱水芽子碱甲酯（AEME）的方法。使用该方法，我们发现，在实验室条件下吸食可卡因的人体受试者尿液中排出大量AEME。当相同受试者通过静脉内和鼻内途径给予可卡因时，尿液中排出的AEME极少（如果有的话）。AEME可能是吸食可卡因（快克）的有用标志物。AEME的药理学尚不清楚。需要研究AEME是否可能在与吸食可卡因相关的效应中发挥作用。
