Saha N, Chugh Y, Sankaranarayanan A, Datta H
Department of Pharmacology, Postgraduate Institute of Medial Education and Research, Chandigarh, India.
Methods Find Exp Clin Pharmacol. 1990 Sep;12(7):507-11.
The effects of ketamine (3, 10 and 30 mg/kg) alone and in combination with verapamil (10 mg/kg) or diltiazem (30 mg/kg) on the acquisition, consolidation and retrieval of memory using a passive avoidance task in mice were studied. Ketamine significantly inhibited the acquisition and consolidation of memory at 10 and 30 mg/kg dose levels and these effects were antagonized by diltiazem 30 mg/kg but not by verapamil 10 mg/kg. Studies of sleeping time demonstrated that pretreatment with verapamil 10 mg/kg increased the duration of sleeping time. Diltiazem, however, did not potentiate the effects of ketamine on sleeping time. The present findings indicate that diltiazem can counter the effects of ketamine on memory. The data also indicates that pretreatment of surgical patients with verapamil may reduce the dose of ketamine required for anesthesia.
研究了单独使用氯胺酮（3、10和30毫克/千克）以及与维拉帕米（10毫克/千克）或地尔硫䓬（30毫克/千克）联合使用对小鼠被动回避任务中记忆的获取、巩固和检索的影响。氯胺酮在10和30毫克/千克剂量水平时显著抑制记忆的获取和巩固，这些作用被30毫克/千克的地尔硫䓬拮抗，但未被10毫克/千克的维拉帕米拮抗。睡眠时间研究表明，10毫克/千克的维拉帕米预处理增加了睡眠时间。然而，地尔硫䓬并未增强氯胺酮对睡眠时间的影响。目前的研究结果表明，地尔硫䓬可以对抗氯胺酮对记忆的影响。数据还表明，用维拉帕米预处理手术患者可能会降低麻醉所需的氯胺酮剂量。
