Valzelli L, Kozak W, Skorupska M
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Methods Find Exp Clin Pharmacol. 1988 Apr;10(4):239-42.
A light ether anesthesia in laboratory mice resulted in the complete drop of their memory retrieval to zero for more than three days after the administration. On the contrary, mice that underwent the exploration test after the light ether anesthesia performed as expected, confirming that impairment of memory does not necessarily reflect on exploratory performance. The effect of some anesthetic drugs was then studied on memory retrieval and exploratory behavior. Within this general framework, the anesthetics here studied all worsen memory retrieval, however without inducing clear and long-lasting amnesic effect comparable to that exerted by ether anesthesia. Contrarily, the classically amnesic drug scopolamine, orally administered, enhances memory retrieval and improves exploration.
对实验小鼠进行轻度乙醚麻醉后，在给药后的三天多时间里，它们的记忆提取能力完全降至零。相反，在轻度乙醚麻醉后进行探索测试的小鼠表现正常，这证实了记忆受损不一定会影响探索行为。随后研究了一些麻醉药物对记忆提取和探索行为的影响。在此总体框架内，这里研究的所有麻醉剂都会使记忆提取能力变差，但不会产生与乙醚麻醉相当的明显且持久的失忆效果。相反，口服经典的失忆药物东莨菪碱会增强记忆提取能力并改善探索行为。
