富含饱和脂肪酸的膳食植物油对糖尿病大鼠血脂谱、抗氧化酶和葡萄糖耐量的影响。
Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats.
机构信息
Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.
出版信息
Indian J Pharmacol. 2010 Jun;42(3):142-5. doi: 10.4103/0253-7613.66835.
OBJECTIVE
To study the effect of saturated fatty acid (SFA)-rich dietary vegetable oils on the lipid profile, endogenous antioxidant enzymes and glucose tolerance in type 2 diabetic rats.
MATERIALS AND METHODS
Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rats. Twenty-eight-day-old normal (N) and diabetic (D) male Wistar rats were fed for 45 days with a fat-enriched special diet (10%) prepared with coconut oil (CO) - lauric acid-rich SFA, palm oil (PO) - palmitic acid-rich SFA and groundnut oil (GNO) - control (N and D). Lipid profile, endogenous antioxidant enzymes and oral glucose tolerance tests were monitored.
RESULTS
D rats fed with CO (D + CO) exhibited a significant decrease in the total cholesterol and non-high-density lipoprotein cholesterol. Besides, they also showed a trend toward improving antioxidant enzymes and glucose tolerance as compared to the D + GNO group, whereas D + PO treatment aggravated the dyslipidemic condition while causing a significant decrease in the superoxide dismutase levels when compared to N rats fed with GNO (N + GNO). D + PO treatment also impaired the glucose tolerance when compared to N + GNO and D + GNO.
CONCLUSION
The type of FA in the dietary oil determines its deleterious or beneficial effects. Lauric acid present in CO may protect against diabetes-induced dyslipidemia.
目的
研究富含饱和脂肪酸（SFA）的膳食植物油对 2 型糖尿病大鼠血脂谱、内源性抗氧化酶和葡萄糖耐量的影响。
材料与方法
通过向新生大鼠腹腔内注射链脲佐菌素（90mg/kg）诱导 2 型糖尿病。28 日龄正常（N）和糖尿病（D）雄性 Wistar 大鼠用富含脂肪的特殊饮食（10%）喂养 45 天，该饮食由富含月桂酸的椰子油（CO）、富含棕榈酸的棕榈油（PO）和花生油（GNO）制成。监测血脂谱、内源性抗氧化酶和口服葡萄糖耐量试验。
结果
用 CO 喂养的 D 大鼠（D+CO）的总胆固醇和非高密度脂蛋白胆固醇显著降低。此外，与 D+GNO 组相比，它们的抗氧化酶和葡萄糖耐量也有改善的趋势，而与 N+GNO 组相比，PO 处理加剧了血脂异常状况，同时导致超氧化物歧化酶水平显著降低。与 N+GNO 和 D+GNO 相比，D+PO 处理也损害了葡萄糖耐量。
结论
膳食油中 FA 的类型决定了其有害或有益的影响。CO 中存在的月桂酸可能有助于预防糖尿病引起的血脂异常。
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