Division of Organ Regeneration Surgery, Department of Surgery, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan.
Surg Today. 2010 Oct;40(10):990-6. doi: 10.1007/s00595-009-4165-8. Epub 2010 Sep 25.
Pheochromocytomas are rare neuroendocrine tumors that produce symptoms through the excess release of catecholamines. The treatment of choice is a complete surgical removal after pretreatment with an α-blocker, to prevent dangerous hemodynamic fluctuations. Newell and colleagues defined the rare, fatal condition of catecholamine crisis, which includes multiple organ failure (MOF), severe blood pressure variability, high fever, and encephalopathy, as pheochromocytoma multisystem crisis (PMC). The indications for emergency surgery in this unstable state still remain controversial. This report presents the case of a 52-year-old female patient with PMC who successfully underwent a surgical resection. This case showed that early tumor removal may be the only means of halting the progression of this disease.
嗜铬细胞瘤是一种罕见的神经内分泌肿瘤，通过过量释放儿茶酚胺产生症状。首选的治疗方法是在使用α受体阻滞剂预处理后进行完全手术切除，以防止危险的血流动力学波动。Newell 及其同事定义了罕见的、致命的儿茶酚胺危象状态，包括多器官衰竭（MOF）、严重的血压变异性、高热和脑病，称为嗜铬细胞瘤多系统危象（PMC）。在这种不稳定状态下进行紧急手术的指征仍存在争议。本报告介绍了一例成功接受手术切除的 PMC 女性患者。该病例表明，早期肿瘤切除可能是阻止疾病进展的唯一手段。
