Department of Microbiology and Immunology, University of North Carolina, Mary Ellen Jones Bldg., Room 635, Campus Box 7290, Chapel Hill, NC 27599-7290, USA.
Arch Immunol Ther Exp (Warsz). 2010 Dec;58(6):449-57. doi: 10.1007/s00005-010-0100-3. Epub 2010 Sep 26.
Events ongoing in the thymus are critical for deleting developing thymocytes specific for tissue antigens, and establishing self-tolerance within the T cell compartment. Aberrant thymic negative selection, however, is believed to generate a repertoire with increased self-reactivity, which in turn can contribute to the development of T cell-mediated autoimmunity. In this review, mechanisms that regulate the efficacy of negative selection and influence the deletion of autoreactive thymocytes will be discussed.
胸腺中的事件对于删除针对组织抗原的发育中的胸腺细胞以及在 T 细胞区室中建立自身耐受至关重要。然而，异常的胸腺阴性选择被认为会产生具有更高自身反应性的 repertoire，这反过来又可能导致 T 细胞介导的自身免疫的发展。在这篇综述中，将讨论调节阴性选择效力的机制以及影响自身反应性胸腺细胞删除的机制。
