Department of Reproductive, Developmental and Public Health Sciences, UCO Hygiene and Preventive Medicine, University of Trieste and IRCCS Burlo Garofolo, Trieste, Italy.
J Med Virol. 2010 Nov;82(11):1976-82. doi: 10.1002/jmv.21874.
From January to June 2008, a rubella outbreak involving 111 laboratory confirmed cases occurred in the Friuli Venezia Giulia (FVG) region of North-Eastern Italy. The outbreak occurred initially in two residential homes for young adults disabled mentally and physically. Subsequently, the epidemic spread to the general population. Young adult cohorts were mostly affected and the mean age of the patients was 26.8 years; the majority of cases were male (73.8%), with a mean age of 26.6 years in males and 27.4 in females. Three pregnant women had a primary infection and two had their pregnancies terminated. Genotyping of 16 isolates showed the circulation of RUBV 2B, a genotype originating from Asia and South Africa and now present in Europe. In addition, molecular analysis revealed a well defined space-temporal spread of two viruses showing distinct sequences. A seroepidemiological survey carried out in a city within the same geographical area showed that the proportion of women of childbearing age still susceptible to rubella virus was 5.5%, fairly close to the figure (<5%) expected by 2010.
2008 年 1 月至 6 月，意大利东北部弗留利-威尼斯朱利亚（Friuli Venezia Giulia，简称 FVG）地区发生了一起涉及 111 例实验室确诊风疹病例的暴发疫情。疫情最初发生在两家精神和身体残疾的青年成人住所。随后，疫情蔓延到了普通人群。青年人群受到了主要影响，患者的平均年龄为 26.8 岁；大多数病例为男性（73.8%），男性的平均年龄为 26.6 岁，女性为 27.4 岁。有 3 名孕妇发生了原发性感染，2 人终止了妊娠。对 16 个分离株的基因分型显示，RUBV 2B 型（一种起源于亚洲和南非、现已在欧洲流行的基因型）正在流行。此外，分子分析显示两种具有不同序列的病毒呈现出明确的时空传播。在同一地理区域内的一个城市进行的血清流行病学调查显示，育龄妇女中仍有 5.5%对风疹病毒易感，这一比例与 2010 年预期的（<5%）值相当接近。
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