Academic Department of Medical and Surgical Gastroenterology, Homerton University Foundation NHS Trust, London, UK.
Br J Surg. 2010 Dec;97(12):1885-9. doi: 10.1002/bjs.7259. Epub 2010 Sep 24.
Stomal complications are prevalent and associated with considerable morbidity. This study examined the incidence and potential risk factors for their development.
The time of onset and presence of ten specific complications were recorded for patients with an intestinal stoma over 10 years at two urban hospitals. A database was established with 20 explanatory variables (such as common medical co-morbidities) derived from the stomatherapy and medical records. Univariable and multivariable analyses were performed to identify potential risk factors for the development of complications.
Some 1216 patients (mean age 64 years) with a minimum of 2 years' follow-up were included, of whom 544 (44·7 per cent) underwent surgery for malignancy and 647 (53·2 per cent) had a colostomy formed. There were 1219 complications in total; 807 major complications (excluding excoriation and slough) occurred in 564 patients (46·4 per cent), of which the commonest was parastomal hernia (171, 14·1 per cent). On multivariable analysis, musculoskeletal co-morbidity (odds ratio (OR) 1·79, 95 per cent confidence interval 1·05 to 3·07; P = 0·032), cancer (OR 1·48, 1·13 to 1·93; P = 0·004) and high American Association of Anesthesiologists score (OR = 3·80, 2·14 to 6·75; P < 0·001) were associated with an increased risk of complications. Preoperative siting was associated with a reduced risk (OR 0·59, 0·39 to 0·90; P = 0·014).
Intestinal stomal complications are common, occurring in almost half of patients. There are certain irremediable risk factors, allowing appropriate preoperative counselling.
造口并发症较为普遍,且与较高的发病率有关。本研究旨在探究其发病的发生率及潜在风险因素。
在两家市级医院,对肠造口患者随访 10 年以上,记录其 10 种特定并发症的发病时间和发病情况。从造口治疗和病历中获取 20 个解释变量(如常见的合并症),建立数据库。采用单变量和多变量分析来确定并发症发生的潜在风险因素。
共纳入 1216 例患者(平均年龄 64 岁),其中 544 例(44.7%)因恶性肿瘤接受手术,647 例(53.2%)行结肠造口术。共有 1219 例并发症,564 例(46.4%)发生 807 例(不包括擦伤和坏死)严重并发症,最常见的是造口旁疝(171 例,14.1%)。多变量分析显示,肌肉骨骼合并症(优势比(OR)1.79,95%置信区间 1.05 至 3.07;P=0.032)、癌症(OR 1.48,1.13 至 1.93;P=0.004)和美国麻醉医师协会评分较高(OR=3.80,2.14 至 6.75;P<0.001)与并发症风险增加相关。术前造口位置与较低的风险相关(OR 0.59,0.39 至 0.90;P=0.014)。
肠造口并发症较为常见,近一半的患者会发生。存在一些不可避免的风险因素,需要在术前进行适当的咨询。