Department of Radiology, Tobata Kyoritsu Hospital, Kitakyushu, Fukuoka, Japan.
Magn Reson Med. 2011 Feb;65(2):595-602. doi: 10.1002/mrm.22614. Epub 2010 Sep 24.
Flow-spoiled fresh blood imaging, a noncontrast peripheral MR angiography technique, allows the depiction of the entire tree of peripheral arteries by utilizing the signal difference between systolic- and diastolic-triggered data. The image quality of the technique relies on selecting the right triggering delay times and flow-dependent read-out spoiler gradient pulses. ECG triggering delays were verified using manual subtraction and automated software. The read-out spoiler gradients pulses were optimized on volunteers before utilizing the flow-spoiled fresh blood imaging technique to screen for peripheral arterial disease. Thirteen consecutive patients with suspected peripheral arterial disease underwent both flow-spoiled fresh blood imaging and 16-detector-row computed tomography angiography examinations. A total of 23 segments were evaluated in the arterial vascular system. Using computed tomography angiography as the reference standard, 56 diseased segments were detected with 22 nonsignificant stenoses (<50%) and 34 significant stenoses, 15 of which were totally occluded. Flow-spoiled fresh blood imaging had a sensitivity of 97%, a specificity of 96%, an accuracy of 96%, a positive predictive value of 88%, and a negative predictive value of 99%. With such a high negative predictive value, flow-spoiled fresh blood imaging has the potential to become the safest noninvasive screening tool for peripheral arterial disease, especially for patients with impaired renal function.
血流spoiled 新鲜血液成像，一种非对比外周磁共振血管成像技术，通过利用收缩期和舒张期触发数据之间的信号差异来描绘外周动脉的整个树。该技术的图像质量依赖于选择正确的触发延迟时间和依赖于流动的读出扰频梯度脉冲。ECG 触发延迟使用手动减法和自动软件进行验证。在使用血流spoiled 新鲜血液成像技术筛查外周动脉疾病之前，在志愿者身上优化读出扰频梯度脉冲。13 例疑似外周动脉疾病的连续患者接受了血流spoiled 新鲜血液成像和 16 排计算机断层血管造影检查。总共在动脉血管系统中评估了 23 个节段。使用计算机断层血管造影作为参考标准，检测到 56 个病变节段，其中 22 个狭窄程度<50%，34 个狭窄程度显著，其中 15 个完全闭塞。血流spoiled 新鲜血液成像的灵敏度为 97%，特异性为 96%，准确性为 96%，阳性预测值为 88%，阴性预测值为 99%。由于如此高的阴性预测值，血流spoiled 新鲜血液成像有可能成为外周动脉疾病最安全的无创筛查工具，尤其是对于肾功能受损的患者。
