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依托考昔与双氯芬酸对骨关节炎和类风湿关节炎患者上消化道安全性和有效性的比较评估（多国依托考昔与双氯芬酸关节炎长期（MEDAL）研究项目）

[Comparative evaluation of the safety and efficacy of etoricoxib and diclofenac on the upper gastrointestinal tract in patients with osteoarthrosis and rheumatoid arthritis (the multinational etoricoxib and diclofenac arthritis long-term (MEDAL) study program)].

作者信息

Alekseeva L I

出版信息

Ter Arkh. 2010;82(8):57-62.

PMID:20873248
Abstract

The review gives and analyzes the data of a number of studies evaluating the safety and efficacy of nonsteroidal anti-inflammatory drugs on the upper gastrointestinal tract. Particular emphasis is laid on the results of the multinational etoricoxib and diclofenac arthritis long-term (MEDAL) study program. The randomized MEDAL study has shown that etoricoxib has more benefits than diclofenac.

摘要

该综述给出并分析了多项评估非甾体抗炎药在上消化道安全性和有效性的研究数据。特别强调了多国依托考昔与双氯芬酸关节炎长期（MEDAL）研究项目的结果。随机的MEDAL研究表明，依托考昔比双氯芬酸更具优势。

相似文献

1
[Comparative evaluation of the safety and efficacy of etoricoxib and diclofenac on the upper gastrointestinal tract in patients with osteoarthrosis and rheumatoid arthritis (the multinational etoricoxib and diclofenac arthritis long-term (MEDAL) study program)].依托考昔与双氯芬酸对骨关节炎和类风湿关节炎患者上消化道安全性和有效性的比较评估（多国依托考昔与双氯芬酸关节炎长期（MEDAL）研究项目）
Ter Arkh. 2010;82(8):57-62.
2
Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis.多国依托考昔与双氯芬酸关节炎长期（MEDAL）研究项目的临床试验设计及患者人口统计学特征：骨关节炎和类风湿关节炎患者中依托考昔与双氯芬酸的心血管结局
Am Heart J. 2006 Aug;152(2):237-45. doi: 10.1016/j.ahj.2006.05.024.
3
Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.在多国依托考昔与双氯芬酸关节炎长期（MEDAL）项目中，依托考昔与双氯芬酸用于骨关节炎和类风湿关节炎患者的心血管结局：一项随机对照研究
Lancet. 2006 Nov 18;368(9549):1771-81. doi: 10.1016/S0140-6736(06)69666-9.
4
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.在多国依托考昔与双氯芬酸关节炎长期（MEDAL）项目中，对骨关节炎和类风湿关节炎患者依托考昔与双氯芬酸的上消化道安全性评估：一项随机对照研究
Lancet. 2007 Feb 10;369(9560):465-73. doi: 10.1016/S0140-6736(07)60234-7.
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[By what means does the rheumatic patient with gastrointestinal risks fare best?].患有胃肠道风险的风湿性疾病患者如何才能获得最佳治疗效果？
MMW Fortschr Med. 2007 Mar 8;149(10):18. doi: 10.1007/BF03370797.
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Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II).依托考昔在类风湿关节炎患者中的胃肠道耐受性：依托考昔与双氯芬酸钠胃肠道耐受性及有效性试验（EDGE-II）结果
Ann Rheum Dis. 2008 Mar;67(3):315-22. doi: 10.1136/ard.2007.082388. Epub 2007 Oct 27.
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Gastrointestinal safety of etoricoxib in osteoarthritis and rheumatoid arthritis: A meta-analysis.依托考昔在骨关节炎和类风湿关节炎中的胃肠道安全性：一项荟萃分析。
PLoS One. 2018 Jan 10;13(1):e0190798. doi: 10.1371/journal.pone.0190798. eCollection 2018.
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Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.依托考昔：新药。避免使用环氧化酶-2抑制剂止痛。
Prescrire Int. 2007 Dec;16(92):223-7.
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[3 questions about gastrointestinal risk. Are coxibs here clearly better than NSAID?]].关于胃肠道风险有3个问题。环氧化酶-2选择性抑制剂在这里明显比非甾体抗炎药更好吗？
MMW Fortschr Med. 2006 Nov 30;148(48):12.
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Gastrointestinal side effects of etoricoxib in patients with osteoarthritis: results of the Etoricoxib versus Diclofenac Sodium Gastrointestinal Tolerability and Effectiveness (EDGE) trial.依托考昔在骨关节炎患者中的胃肠道副作用：依托考昔与双氯芬酸钠胃肠道耐受性及有效性（EDGE）试验结果
J Rheumatol. 2007 Feb;34(2):408-20.

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