Ouangraoua Aïda, Bergeron Anne
Department of Mathematics, Simon Fraser University, Burnaby, BC, Canada.
J Comput Biol. 2010 Sep;17(9):1129-44. doi: 10.1089/cmb.2010.0126.
In genome rearrangement theory, one of the elusive questions raised in recent years is the enumeration of rearrangement scenarios between two genomes. This problem is related to the uniform generation of rearrangement scenarios and the derivation of tests of statistical significance of the properties of these scenarios. Here we give an exact formula for the number of double-cut-and-join (DCJ) rearrangement scenarios between two genomes. We also construct effective bijections between the set of scenarios that sort a component as well studied combinatorial objects such as parking functions, labeled trees, and prüfer codes.
在基因组重排理论中,近年来提出的一个难以捉摸的问题是两个基因组之间重排情形的计数。这个问题与重排情形的均匀生成以及这些情形属性的统计显著性检验的推导有关。在这里,我们给出了两个基因组之间双切割连接(DCJ)重排情形数量的精确公式。我们还在将一个组件排序的情形集与一些研究充分的组合对象(如停车函数、标记树和普吕弗编码)之间构建了有效的双射。