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丹麦学龄儿童哮喘和支气管高反应性的流行情况:10 年来没有变化。

Prevalence of asthma and bronchial hyperreactivity in Danish schoolchildren: no change over 10 years.

机构信息

Department of Pediatrics, Herlev Hospital, University of Copenhagen, Herlev, Denmark.

出版信息

Acta Paediatr. 2011 Mar;100(3):385-9. doi: 10.1111/j.1651-2227.2010.02036.x. Epub 2010 Oct 25.

Abstract

AIM

To describe the point prevalence of current physician-diagnosed asthma and bronchial hyperreactivity (BHR) in 2001 among unselected Danish schoolchildren aged 6-17 years, compared with the prevalence from a similar study from 1990 to 1991.

METHODS

Cross-sectional study using parental questionnaire on asthma and respiratory symptoms combined with a 6-min free running test with peak expiratory flow rate (PEFR) measurement (n = 1051, response rate 89.3%). Results were compared with those of a similar study in the same area from 1990 to 1991. Main outcome measures were current physician-diagnosed asthma or BHR in children without physician-diagnosed asthma measured by either a decrease in lung function after standardized running test and/or variability in PEFR on home monitoring.

RESULTS

The prevalence of current physician-diagnosed asthma was 4.0% [95% confidence interval (CI) 2.7-5.3%] in 1990-1991 and 3.6% (95% CI 2.4-4.8%) in 2001. The prevalence of BHR was 3.2% (95% CI 2.0-4.4%) in 1990-1991 and 2.0% (95% CI 1.1-2.9%) in 2001. The combined prevalence was 7.2% (95% CI 5.4-8.9%) in 1990-1991 and 5.6% (95% CI 4.2-7.1%) in 2001.

CONCLUSION

The point prevalence of current physician-diagnosed asthma and BHR among unselected Danish schoolchildren aged 6-17 years was unchanged over 10 years between 1990-1991 and 2001.

摘要

目的

描述丹麦未选择的 6-17 岁学龄儿童中,2001 年当前医生诊断的哮喘和支气管高反应性(BHR)的时点患病率,并与 1990 至 1991 年类似研究的患病率进行比较。

方法

采用父母问卷调查哮喘和呼吸道症状,并结合 6 分钟自由跑步测试和峰流速(PEFR)测量(n=1051,应答率 89.3%)的横断面研究。结果与同一地区 1990 至 1991 年类似研究进行比较。主要结局测量为通过标准化跑步试验后肺功能下降和/或家庭监测时 PEFR 变异性来测量的,未经医生诊断哮喘的儿童中当前医生诊断的哮喘或 BHR。

结果

1990-1991 年当前医生诊断的哮喘患病率为 4.0%(95%可信区间 2.7-5.3%),2001 年为 3.6%(95%可信区间 2.4-4.8%)。1990-1991 年 BHR 的患病率为 3.2%(95%可信区间 2.0-4.4%),2001 年为 2.0%(95%可信区间 1.1-2.9%)。联合患病率为 1990-1991 年 7.2%(95%可信区间 5.4-8.9%),2001 年为 5.6%(95%可信区间 4.2-7.1%)。

结论

在 1990-1991 年和 2001 年之间,未选择的丹麦 6-17 岁学龄儿童中,当前医生诊断的哮喘和 BHR 的时点患病率在 10 年内没有变化。

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