七氟醚后处理减轻大鼠海马氧葡萄糖剥夺再灌注损伤。
Sevoflurane postconditioning ameliorates oxygen-glucose deprivation-reperfusion injury in the rat hippocampus.
机构信息
Department of Anesthesiology, Affiliated No. 4 Hospital of Suzhou University, Wuxi, PR China.
出版信息
CNS Neurosci Ther. 2011 Dec;17(6):605-11. doi: 10.1111/j.1755-5949.2010.00193.x. Epub 2010 Sep 28.
Abstract
INTRODUCTION
Sevoflurane is well known to exert a neuroprotective effect through anesthetic preconditioning. However, its effects on postconditioning, a neuroprotective phenomenon following an insult, have not been well studied.
AIMS
In this study, we examined the ability of sevoflurane to induce postconditioning in rat hippocampal slices, in vitro.
RESULTS
2%, 4%, and 6% sevoflurane reduced neurophysiologic and morphologic neuronal injury following oxygen-glucose deprivation (OGD) and reperfusion. The quantity of damaged neurons was significantly reduced on immunofluorescence staining; excitatory amino acids (Asp, Glu) increased and inhibitory amino acids (GABA) decreased significantly. The effect was concentration-dependent.
CONCLUSION
Postconditioning with sevoflurane reduces neuronal damage after OGD-reperfusion injury in the CA1 area of rat hippocampus, in vitro.
摘要
简介
七氟醚通过麻醉预处理发挥神经保护作用已广为人知。然而，其对再灌注后处理（一种损伤后的神经保护现象）的影响尚未得到充分研究。
目的
本研究旨在探讨七氟醚在体外诱导大鼠海马切片再灌注后处理的能力。
结果
2%、4%和 6%七氟醚可减轻氧葡萄糖剥夺（OGD）和再灌注后的神经生理和形态学神经元损伤。免疫荧光染色显示神经元损伤数量明显减少；兴奋性氨基酸（Asp、Glu）显著增加，抑制性氨基酸（GABA）显著减少。这种作用具有浓度依赖性。
结论
七氟醚后处理可减少体外大鼠海马 CA1 区 OGD 再灌注损伤后的神经元损伤。
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