Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, UFJF, Juiz de Fora, MG, Brazil.
Microsc Microanal. 2010 Dec;16(6):653-60. doi: 10.1017/S1431927610093864. Epub 2010 Sep 27.
Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.
机制调控蛋白的分泌是人类嗜酸性粒细胞生物学活性和功能的基础，嗜酸性粒细胞属于天然免疫系统中的白细胞，参与过敏、炎症和免疫调节反应。在受到不同刺激时，嗜酸性粒细胞会从循环系统中募集到炎症部位，通过释放颗粒衍生产物来调节免疫反应。透射电子显微镜（TEM）是唯一能够明确识别和区分不同细胞分泌模式的技术。在这篇综述中，我们根据过去几年中基于 TEM 研究结果的发现，重点介绍了对嗜酸性粒细胞分泌机制的理解进展，这些发现为这些细胞的功能能力提供了前所未有的见解。
