Weihrauch Tobias, Melo Rossana C N, Gray Natalie, Voehringer David, Weller Peter F, Raap Ulrike
Division of Experimental Allergy and Immunodermatology, Faculty of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences (ICB), Federal University of Juiz de Fora, UFJF, Juiz de Fora, Brazil.
Front Allergy. 2024 Aug 1;5:1448007. doi: 10.3389/falgy.2024.1448007. eCollection 2024.
Eosinophil granulocytes, a specialized subset of white blood cells, have traditionally been associated with allergic responses and parasitic infections. However, recent research has unveiled their versatile roles in immune regulation beyond these classical functions. This review highlights the emerging field of eosinophil biology, with a particular focus on their release of extracellular vesicles (EVs) and extracellular DNA traps (EETs). It further explores potential implications of eosinophil-derived EVs and EETs for immune responses during inflammatory diseases. The release of EVs/EETs from eosinophils, which also affects the eosinophils themselves, may influence both local and systemic immune reactions, affecting the pathophysiology of conditions such as airway inflammation, chronic rhinosinusitis and atopic dermatitis.
嗜酸性粒细胞是白细胞的一个特殊亚群，传统上一直与过敏反应和寄生虫感染相关。然而，最近的研究揭示了它们在这些经典功能之外的免疫调节中的多种作用。本综述重点介绍了嗜酸性粒细胞生物学这一新兴领域，特别关注其细胞外囊泡（EVs）和细胞外DNA陷阱（EETs）的释放。它进一步探讨了嗜酸性粒细胞衍生的EVs和EETs对炎症性疾病免疫反应的潜在影响。嗜酸性粒细胞释放的EVs/EETs也会影响嗜酸性粒细胞自身，可能影响局部和全身免疫反应，影响气道炎症、慢性鼻-鼻窦炎和特应性皮炎等疾病的病理生理学。
