Department of Nutrition and Food Sciences, Faculty of Agronomic Sciences, University of Abomey Calavi, 01 BP 526, Cotonou, Benin.
Br J Nutr. 2011 Feb;105(4):574-9. doi: 10.1017/S0007114510003776. Epub 2010 Sep 28.
The present study investigated the association between weight status and Fe deficiency (ID) among urban Malian women of reproductive age. Height, weight, serum ferritin (SF), soluble transferrin receptor (sTfR) and C-reactive protein (CRP) concentrations were measured in sixty apparently healthy women aged 15-49 years old in Bamako, Mali. Prevalences of overweight and obese were 19 and 9 %, respectively. SF was non-significantly different between overweight (84 μg/l) and normal-weight women (52 μg/l). The prevalence of ID (SF < 12 μg/l) was 9 % in the overweight group and no true ID (sTfR>8·3 mg/l) cases were recorded in the overweight and obese groups. The prevalence OR of ID (SF < 12 μg/l) in the overweight group was NS (OR = 0·3; P = 0·363). Conversely, the chronic energy deficiency group was at a significantly higher risk of ID than the normal-weight group, adjusting or not for CRP (OR = 7·7; 95 % CI 1·49, 39·96; P = 0·015). The lack of association between overweight and ID in the present study could be due to the fact that the excess of body fat of the women might not be critical to induce chronic inflammation related to reduced Fe absorption. Future research based on a larger convenience sample should be designed to further investigate associations between overweight, obesity and ID in developing countries.
本研究调查了马里育龄城市妇女的体重状况与铁缺乏症 (ID) 之间的关联。在马里巴马科，对 60 名年龄在 15-49 岁的明显健康的女性测量了身高、体重、血清铁蛋白 (SF)、可溶性转铁蛋白受体 (sTfR) 和 C 反应蛋白 (CRP) 浓度。超重和肥胖的患病率分别为 19%和 9%。超重者 (84μg/l) 和正常体重者 (52μg/l) 的 SF 无显著差异。超重组 ID（SF<12μg/l）的患病率为 9%，超重和肥胖组未记录到真正的 ID（sTfR>8.3mg/l）病例。超重组 ID（SF<12μg/l）的患病率 OR 无统计学意义（OR=0.3；P=0.363）。相反，调整或不调整 CRP 后，慢性能量缺乏组的 ID 风险明显高于正常体重组（OR=7.7；95%CI 1.49, 39.96；P=0.015）。本研究中超重与 ID 之间缺乏关联可能是由于女性体脂肪过多不一定会导致与铁吸收减少相关的慢性炎症。应该设计基于更大便利样本的未来研究，以进一步调查发展中国家超重、肥胖与 ID 之间的关联。
