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RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway.RACK1 通过激活 RhoA/Rho 激酶通路促进乳腺癌迁移/转移。
Breast Cancer Res Treat. 2011 Apr;126(3):555-63. doi: 10.1007/s10549-010-0955-3. Epub 2010 May 25.
2
RACK1, a PKC targeting protein, is exclusively localized to basal airway epithelial cells.RACK1是一种蛋白激酶C靶向蛋白，仅定位于气道基底上皮细胞。
J Histochem Cytochem. 2008 Jan;56(1):7-14. doi: 10.1369/jhc.7A7249.2007. Epub 2007 Sep 17.
3
Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle.Rho激酶在大鼠支气管平滑肌中内皮素-1诱导的CPI-17磷酸化中的作用
Pulm Pharmacol Ther. 2007;20(6):734-9. doi: 10.1016/j.pupt.2006.08.011. Epub 2006 Sep 22.
4
Augmentation of endothelin-1-induced phosphorylation of CPI-17 and myosin light chain in bronchial smooth muscle from airway hyperresponsive rats.气道高反应性大鼠支气管平滑肌中内皮素-1诱导的CPI-17和肌球蛋白轻链磷酸化增强。
Biol Pharm Bull. 2006 Sep;29(9):1897-9. doi: 10.1248/bpb.29.1897.
5
Localization of the scaffolding protein RACK1 in the developing and adult mouse brain.支架蛋白RACK1在发育中和成年小鼠大脑中的定位。
Brain Res. 2006 Jan 19;1069(1):31-8. doi: 10.1016/j.brainres.2005.11.018. Epub 2006 Jan 18.
6
Acetylcholine-induced phosphorylation and membrane translocation of CPI-17 in bronchial smooth muscle of rats.乙酰胆碱诱导大鼠支气管平滑肌中CPI-17的磷酸化及膜转位
Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L925-30. doi: 10.1152/ajplung.00054.2005. Epub 2005 Jul 22.
7
Acetylcholine-induced phosphorylation of CPI-17 in rat bronchial smooth muscle: the roles of Rho-kinase and protein kinase C.乙酰胆碱诱导大鼠支气管平滑肌中CPI-17的磷酸化：Rho激酶和蛋白激酶C的作用
Can J Physiol Pharmacol. 2005 Apr;83(4):375-81. doi: 10.1139/y05-022.
8
Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyper-responsive rats.CPI-17可能参与抗原诱导的气道高反应性大鼠支气管平滑肌收缩增强过程。
Mol Pharmacol. 2005 Jul;68(1):145-51. doi: 10.1124/mol.104.004325. Epub 2005 Apr 6.
9
The role of RhoA-mediated Ca2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness.RhoA介导的支气管平滑肌收缩的Ca2+致敏在气道高反应性中的作用。
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Association of CPI-17 with protein kinase C and casein kinase I.CPI-17与蛋白激酶C和酪蛋白激酶I的关联
Biochem Biophys Res Commun. 2004 Mar 26;316(1):39-47. doi: 10.1016/j.bbrc.2004.02.014.

在支气管平滑肌细胞中 CPI-17 和 RACK1 蛋白之间的功能相互作用。

A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.

机构信息

Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

出版信息

Biochem Biophys Res Commun. 2010 Oct 22;401(3):487-90. doi: 10.1016/j.bbrc.2010.09.086. Epub 2010 Sep 25.

DOI:10.1016/j.bbrc.2010.09.086
PMID:20875397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486735/
Abstract

CPI-17 is a phosphorylation-dependent inhibitor of smooth muscle myosin light chain. Using yeast two-hybrid system, we have identified the receptor for activated C kinase 1 (RACK1) as a novel interaction partner of CPI-17. The direct interaction and co-localization of CPI-17 with RACK1 were confirmed by immunoprecipitation and confocal microscopy analysis, respectively. An in vitro assay system using recombinant/purified proteins revealed that the PKC-mediated phosphorylation of CPI-17 was augmented in the presence of RACK1. These results suggest that RACK1 may play a role in PKC/CPI-17 signaling pathway.

摘要

CPI-17 是一种磷酸化依赖性的平滑肌肌球蛋白轻链抑制剂。我们利用酵母双杂交系统鉴定出蛋白激酶 C 激活受体 1（RACK1）是 CPI-17 的一个新的相互作用伙伴。免疫沉淀和共聚焦显微镜分析分别证实了 CPI-17 与 RACK1 的直接相互作用和共定位。利用重组/纯化蛋白的体外测定系统表明，在 RACK1 存在的情况下，PKC 介导的 CPI-17 磷酸化增强。这些结果表明，RACK1 可能在 PKC/CPI-17 信号通路中发挥作用。