Cell Adhesion Unit, Division of Neuroscience, San Raffaele Scientific Institute and San Raffaele University, 20132 Milano, Italy.
Exp Cell Res. 2011 Jan 1;317(1):1-8. doi: 10.1016/j.yexcr.2010.09.014. Epub 2010 Sep 25.
Liprins have been known for years to play an essential role in setting up functional synapses in the nervous system. On the other hand, these proteins had been first identified in non-neuronal cells as multivalent proteins that may affect the integrin-mediated interactions of the cells with extracellular matrix ligands. Although the research on the function of liprins in non-neuronal cells has been quiescent for several years, a number of recent findings are putting them back on stage again as important players also in the regulation of non-neuronal cell motility, and possibly of tumor cell behavior. The aim of this review is to highlight the findings supporting the importance of liprins as central regulators of cell adhesion and motility, making them an interesting family of proteins to be considered for future studies on the mechanisms regulating cell migration.
多年来，脂联素一直被认为在神经系统中形成功能性突触中发挥着重要作用。另一方面，这些蛋白质最初在非神经元细胞中被鉴定为多价蛋白，可能影响细胞与细胞外基质配体的整合素介导的相互作用。尽管近年来对脂联素在非神经元细胞中的功能研究一直处于沉寂状态，但最近的一些发现又将其重新作为重要的调控因子，参与非神经元细胞运动的调节，可能还有肿瘤细胞行为的调节。本综述的目的是强调支持脂联素作为细胞黏附和运动的中央调节剂的重要性的研究发现，使它们成为未来研究调节细胞迁移的机制时值得考虑的一类有趣的蛋白质。
