Dabbagh Ali, Rajaei Samira, Shamsolahrar Mohammad Hasan
Anesthesiology Research Center, Shahid Beheshti University of Medicine, Tehran, Iran.
J Perianesth Nurs. 2010 Oct;25(5):290-5. doi: 10.1016/j.jopan.2010.07.002.
Postoperative blood drainage is a great concern for health care providers when monitoring patients after cardiac surgery. In this study, the effect of intravenous magnesium sulfate infusion on postoperative bleeding in patients undergoing elective coronary artery bypass graft (CABG) surgeries was assessed. In a double-blind, randomized placebo-controlled clinical trial, 140 patients scheduled for elective CABG were randomly assigned into two groups; one group receiving intravenous magnesium sulfate and one receiving placebo. All the cases were similar regarding anesthesia and surgery. The magnesium group had less postoperative bleeding (465 ± 130 mL vs 680 ± 190 mL in the placebo group; P = .00) and less packed cell use (2.1 ± 0.6 packs vs 3.2 ± 0.8 packs in the placebo group; P < .05) as compared with placebo. The results demonstrated significantly less postoperative bleeding and packed cell use in the group receiving intravenous magnesium sulfate infusion during elective CABG surgery.
术后引流是心脏手术后监测患者时医疗保健人员极为关注的问题。在本研究中，评估了静脉输注硫酸镁对择期冠状动脉旁路移植术（CABG）患者术后出血的影响。在一项双盲、随机、安慰剂对照的临床试验中，140例计划进行择期CABG的患者被随机分为两组；一组接受静脉输注硫酸镁，另一组接受安慰剂。所有病例在麻醉和手术方面均相似。与安慰剂组相比，硫酸镁组术后出血量更少（465±130 mL vs安慰剂组680±190 mL；P = 0.00），红细胞压积使用量更少（2.1±0.6单位vs安慰剂组3.2±0.8单位；P<0.05）。结果表明，在择期CABG手术期间接受静脉输注硫酸镁的组术后出血和红细胞压积使用量明显更少。
